The northbound lane of the Tuggeranong Parkway was blocked after cars crashed into each nose to tail.
Police said the accident was between Hindmarsh Drive and Cotter Road.
It is not believed anyone was seriously injured. Police urged people to find alternative routes as emergency services worked to clear the road.
Disruptive crashes are almost a daily Canberra occurrence at the moment.
On Monday, a truck hit a light pole on Kingsford Smith Drive, causing a road block.
The police said the driver of the truck was taken to hospital but the injuries were not thought to be serious.
The accident happened near the junction with Chinner Crescent, near Melba shops.
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