Trams have been stopped between Ashton-under-Lyne and Droylsden following a crash on the tracks at Audenshaw.
Emergency services were called to Droylsden Road just before 10.45am on Friday morning to reports of a collision involving an Audi A6 and a Metrolink tram.
The crash reportedly happened close to the BP garage.
It is understood one person suffered minor injuries and was treated at the scene by ambulance crews.
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The line is currently blocked in both directions, however tickets and passes are being accepted on several local bus services.
Metrolink tweeted: "Due to a road traffic collision, there are NO services operating between Droylsden and Ashton.
"Tickets and passes can be used on bus services 216, 217, 230 & 231. We apologise for any inconvenience caused."
Stagecoach GM also tweeted to say diversions were in place.
A spokesman for Greater Manchester Fire and Rescue said three crews - as well as a Technical Response Unit - were on scene.
They added: "We were called at 10.42 to Droylsden Road in Audenshaw to reports of a collision involving an Audi A6 and a tram.
"All persons had self rescued by the time we arrived.
"We are still on scene."
