Xavi Simons makes his Tottenham debut against West Ham.
The 22-year-old signed for £51.8million from RB Leipzig in the final days of the transfer window, before heading off on international duty with the Netherlands.
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Fellow new signing Randal Kolo Muani is also in the squad at the London Stadium, but manager Thomas Frank has opted to start the Dutchman against the Hammers.
"Both of them are looking good," Thomas Frank said at his press conference on Friday.
"Both of them are definitely in contention to be ready for the squad. Xavi, for natural reasons, is further down the line. He just started the first game for Holland and played a few games for Leipzig.
"Definitely in terms of Randal, it's been a while since he's played. Last time was in the Club World Cup. Hasn't trained really with PSG. So he is not as fit as Xavi, but he looks good."
Simons gets the nod on No10, which means Rodrigo Bentancur is the one who drops to the bench.
Frank will again be without Dominic Solanke, who remains unavailable due to an ankle injury.
The Spurs boss said the striker was "not too far away", but it means Mathys Tel leads the line over Richarlison who endured a long trip back to the UK after starting for Brazil on Tuesday night.
Confirmed team news
Tottenham XI: Vicario, Pedro Porro, Romero (c), van de Ven, Spence, Bergvall, Palhinha, Sarr, Xavi, Tel, Kudus.
Subs: Kinsky, Danso, Davies, Udogie, Bentancur, Odobert, Johnson, Richarlison, Kolo Muani.
