Left-back remains Jose Mourinho's problem position as Tottenham face Southampton for the second time in just over three weeks.
Ben Davies is still unfit, Danny Rose is up for sale and Ryan Sessegnon struggled against Norwich, conceding a second-half penalty to support Mourinho's claim that the teenager is still not ready to play in the back four.
Mourinho has opted for Japhet Tanganga at left-back for today's FA Cup fourth-round tie, with Davinson Sanchez partnering Toby Alderweireld in the heart of defence.
Harry Winks starts after recovering from a recent ankle problem, while new signing Gedson Fernandes plays alongside him in midfield.
Christian Eriksen has also travelled despite ongoing talks with Inter Milan over a January transfer, but is not included in the 18-man squad.
Tottenham lineup: Lloris, Aurier, Alderweireld, Sanchez, Tanganga, Winks, Gedson, Lo Celso, Dele, Son, Lucas
Subs: Gazzaniga, Foyth, Vertonghen, Dier, Ndombele, Sessegnon, Lamela
