Giovani Lo Celso and Erik Lamela were injured for Tottenham's FA Cup fourth-round replay with Southampton.
Dele Alli was only fit enough for the bench after his injury at the weekend, so there was a first start since New Year's Day for Tanguy Ndombele.
Steve Bergwijn was ineligible as he did not sign for Spurs in time for the intial FA Cup fixture between this sides, which finished 1-1 at St. Mary's last month.
Stuart Armstrong missed out for Saints with a hip problem but it was an otherwise strong side named by Ralph Hasenhuttl.
Jack Ward-Prowse filled in with Kyle Walker-Peters ineligible.
Tottenham XI: Lloris; Aurier, Alderweireld, Vertonghen, Tanganga; Winks, Dier, Ndombele; Sessegnon, Lucas
Subs: Gazzaniga, Sanchez, Cirkin, Skipp, Gedson, Dele, Parrott.
