Kane has been unwell this week and there were fears he could miss the trip to Carrow Road as Spurs bid to seal fourth spot and a place in the Champions League.
But Antonio Conte has named the England captain in his starting XI in a huge boost for Tottenham.
Spurs know know that anything but defeat will guarantee them a place in the Champions League next season.
Before Tottenham’s last game, a 1-0 victory over Burnley, Conte revealed his squad had been hit by a stomach bug which impacted four players.
Dejan Kulusevski was one of four players who had reported symptoms including sickness and started on the bench against Burnley.
But Kulusevski returns to the Spurs side today in place of Lucas Moura.
Heung min-Son starts for Spurs as he chases the Golden Boot at Carrow Road today.
Son is one goal behind Liverpool’s Mohamed Salah leads, who is the top scorer in the Premier League with 22 goals but is on the bench for Liverpool in their game against Wolves.
Tottenham XI: Lloris, Sanchez, Dier, Davies, Emerson, Hojbjerg, Bentancur, Sessegnon, Kulusevski, Son, Kane.
Subs: Gollini, Winks, Rodon, Bergwijn, Lucas, White, Scarlett, Devine, Craig.
When: Sunday, May 22, 4pm BST
Venue: Carrow Road
Referee: Chris Kavanagh