Jose Mourinho has made changes from Saturday’s 2-0 win at Manchester City for the visit of Ludogorets, but the Tottenham manager is short of centre-backs after Toby Alderweireld’s groin strain.
With Joe Rodon ineligible, Japhet Tanganga and Davinson Sanchez start in the heart of defence.
Tanganga makes his second appearance of the season, while Matt Doherty is back contracting coronavirus on international duty.
In midfield, Harry Winks has recovered from a knock, while Dele Alli makes a rare start alongside Tanguy Ndombele.
Mourinho rings the changes up front, with Carlos Vinicius, Gareth Bale and Lucas Moura all playing, although he will not be shy about introducing Harry Kane and Heung-min Son from a 12-man bench if the deputies fail to dazzle.
Joe Hart and Hugo Lloris have tended to rotate in goal for the Europa League, and the former England No.1 has a rare opportunity against the Bulgarians.
Tottenham lineup: Hart, Doherty, Sanchez, Tanganga, Davies (C), Winks, Ndombele, Dele, Lucas, Bale, Vinicius
Subs: Austin, Whiteman, Aurier, Dier, Reguilon, Hojbjerg, Sissoko, Kane, Son, Clarke, White, Scarlett
Thursday, 8pm, BT Sport
Venue: Tottenham Hotspur Stadium
Referee: Giorgi Kruashvili (GEO)
Tottenham squad from: Lloris, Hart, Austin, Whiteman, Doherty, Aurier, Tanganga, Reguilon, Davies, Dier, Sanchez, Cirkin, Hojbjerg, Winks, Sissoko, Dele, White, Clarke, Lo Celso, Ndombele, Lucas, Bergwijn, Bale, Son, Kane, Vinicius.
Doubts: Doherty (fitness)
Injured: Lamela (achilles), Alderweireld (groin)
Ineligible: Gazzaniga, Rose, Rodon, Gedson
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