Jose Mourinho has resisted the temptation to hand Gareth Bale a first Premier League start of his second Tottenham spell at Burnley.
The Welshman did not look fully up to speed in an hour run out against LASK, despite bagging an assist.
Tanguy Ndombele was also given a night off in the Europa League and the Frenchman lines up in midfield Pierre-Emile Hojbjerg and Moussa Sissoko.
At the back, Mourinho brings in Eric Dier after missing the last two games through injury and Davinson Sanchez uncomfortable on the left of a back two in the 3-3 draw with West Ham.
Ben Davies also starts with Sergio Reguilon on the bench, while Heung-min Son, Harry Kane and Lucas Moura start in attack.
Burnley XI: Pope, Lowton, Long, Tarkowski, Taylor, Gudmundsson, Westwood, Brownhill, McNeil, Barnes, Wood
Subs: Brady, Peacock-Farrell, Stephens, Rodriguez, Vydra, Dunne, Benson
Tottenham XI: Lloris, Doherty, Alderweireld, Dier, Davies, Sissoko, Hojbjerg, Lucas Moura, Ndombele, Son, Kane
Subs: Reguilon, Bale, Lamela, Hart, Rodon, Lo Celso, Vinicius
Referee: Michael Oliver
