A difficult evening for Danny Rose against Olympiacos could pave the way for Tottenham boss Jose Mourinho to use his third left-back in as many games.
Selecting Jan Vertonghen, who is better suited to Rose at tucking in to form a back-three, at full-back would allow the rejuvenated Serge Aurier freedom to attack.
Harry Winks must also be fearing for his place after a sloppy first half against the Greeks, with fit-again Tanguy Ndombele pushing for a first start under the Portuguese, but Eric Dier should stay put despite being hooked inside half-an-hour on Tuesday night.
With Lucas Moura having impressed in the past week, the front four continues to pick itself but Giovani Lo Celso will be hard for Mourinho to ignore long-term and could come in if the boss detects any fatigue.
Predicted Tottenham XI (4-2-3-1): Gazzaniga; Aurier, Alderweireld, Sanchez, Vertonghen; Ndombele, Dier; Lucas, Alli, Son; Kane.
