Jose Mourinho has left 10 senior players behind for the trip to Bayern Munich, with Harry Kane, Dele Alli, Jan Vertonghen and Serge Aurier joining six injured Tottenham stars by remaining in London.
Those absentees should pave the way for a host of young players to start at the Allianz Arena in the Champions League dead-rubber.
The big question is how many minutes Mourinho gives to 17-year-old prodigy Troy Parrott, who made his Premier League debut on Saturday.
The Republic of Ireland international is probably more likely to be among the substitutes, although Ryan Sessegnon should finally make his long-awaited full debut, and Kyle Walker-Peters, Juan Foyth and Giovani Lo Celso are also pushing for starts.
The experience is likely to be provided by Christian Eriksen, who is also yet to start a game under Mourinho, while Toby Alderweireld, Danny Rose and Moussa Sissoko could also add some further know-how to the starting XI.
Predicted Tottenham XI (4-2-3-1): Gazzaniga; Walker-Peters, Foyth, Alderweireld, Rose; Sissoko, Dier; Eriksen, Lo Celso, Sessegnon; Lucas.
