Joe Rodon, Japhet Tanganga and Carlos Vinicius start for Tottenham against Aston Villa as Jose Mourinho rings the changes after Thursday's humiliating Europa League exit to Dinamo Zagreb.
Tanganga, Rodon, Vinicius, Pierre-Emile Hojbjerg, Tanguy Ndombele and Giovani Lo Celso all come into the team at Villa Park.
Mourinho, who questioned the attitude and professionalism of his players following the 3-0 defeat against Dinamo, has left Gareth Bale and Dele Alli on the bench.
Serge Aurier and Toby Alderweireld ill. Matt Doherty and Harry Winks have been dropped from the squad.
Tanganga comes in at right-back, while Rodon starts alongside Davinson Sanchez at centre-back.
With Heung-min Son out with a hamstring strain and Erik Lamela suspended, Lo Celso has been handed a first start since December after showing fight from the bench against Dinamo.
Vinicius and Harry Kane start together for the first time.
Youngsters Dane Scarlett and Alfie Devine are on the bench.
Aston Villa are without Jack Grealish, who misses out through injury.
Tottenham line-up: Lloris, Tanganga, Rodon, Sanchez, Reguilon, Hojbjerg, Ndombele, Lo Celso, Lucas, Vinicius, Kane.
Subs: Hart, Dier, Davies, Sissoko, Dele, Bergwijn, Bale, Scarlett, Devine.
