Jose Mourinho named Tanguy Ndombele and Giovani Lo Celso on the bench for Sunday's trip to Aston VIlla.
The Portuguese was never likely to consider Ndombele for both Villa Park and the subsequent Champions League clash with RB Leipzig, and the Frenchman feels better suited to a home European match.
Lo Celso is named alongside Ndombele on the bench, with Eric Dier starting next to Harry Winks and Dele Alli in a midfield three at Villa Park.
Dele starts, despite the Football Association's ongoing investigation into his Snapchat video about the coronavirus outbreak.
Mourinho has put Ben Davies straight back into the team, with Japhet Tanganga on the bench.
Steven Bergwijn is back again after missing the win over Saints and returns to the front three, along with Heung-min Son and Lucas Moura.
Confirmed Tottenham XI (4-3-3): Lloris; Aurier, Alderweireld, Sanchez, Davies; Dier, Dele, Winks; Bergwijn, Lucas, Son
Substitutes: Gazzaniga, Vertonghen, Tanganga, Skipp, Ndombele, Gedson, Lo Celso
