Antonio Conte will be looking to build on his side's performance against Liverpool when Tottenham welcome West Ham.
Tottenham are the favourites with Grosvenor Sport at 11/10 while West Ham are 13/5 and a draw is 5/2.
Conte will be frustrated to see his Spurs side forfeit their place in the Europa Conference League but could give Spurs the chance to win their first piece of silverware in the Carabao Cup.
The north London club have beaten Wolves and Burnley so far while the Irons have beaten both Manchester clubs to get to the quarter-finals.
The hosts' season has suffered multiple postponements with snow and COVID-19 stopping them from finding their rhythm under Conte but their 2-2 draw to title challengers Liverpool suggest they are on the right track.
Follow the Inside Track on Facebook and Twitter.
Tips
18+ | Gamble responsibly | begambleaware.org | Odds subject to change
Players to watch
Michail Antonio loves a game against Tottenham and tonight will be no different.
The West Ham striker has played them 11 times and found the net on six occasions - only Watford are the only team he has scored more goals against with seven.
Meanwhile, we are finally seeing the Harry Kane we all know and Spurs fans love - which could be a headache for West Ham's defence.
Kane finally got his first Premier League goal under Antonio Conte and looked very sharp under the Italian's system which could resurrect the England captain's season.
H2H
This will be the 159th meeting between the two sides with Tottenham picking up 67 wins, 38 draws and 53 defeats.
This will be the 11th meeting between the sides in the League Cup with both sides picking up four wins and two draws after 90 minutes .
Gamble responsibly
Everyone at The Inside Track and Reach are committed to promoting safer gambling. All of our content and recommended bets are advised to those aged 18 or over.
We strongly encourage our readers to only ever bet what they can afford to lose. For more information, please call the National Gambling Helpline on 0808 8020 133 or visit begambleaware.org.