Tottenham have won all four of their matches, without conceding a single goal, since they moved into their new home following their stint at Wembley.
West Ham would need to end a dismal away record, having not won on the road since the turn of the year, if they are to shock their London rivals.
Yet the Hammers were the first visiting team to beat Arsenal at the Emirates in 2007 and their fans will be desperate to pull off a notable north London double.
Speaking in his Standard Sport column, Mark Noble said: "It’s no coincidence that Spurs, with the facilities they have — the stadium and the training ground — are where they are.
"We’re just hoping, though, that we can be the first team to score there. If we do that and don’t concede, we’ll be taking the points back to east London."
Here's how you can see the action on TV and online...
TV channel, live stream and online coverage
The match will be shown live on Sky Sports' Premier League and Main Event channels, and is available via Now TV with a day pass on offer for £8.99.
Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app.
You can also follow all the action with Standard Sport's LIVE blog.
