Tottenham Hotspur will be looking to set the right tone under new boss Nuno Espirito Santo as they look to fae a Manchester City side starting their title defence.
Spurs are the outsiders despite home advantage at 17/4 while the Premier League champions are 4/6 favourites with Grosvenor Sport and a draw is 14/5.
The game will be more focused on one player in Harry Kane as the striker continues his search for a new club, with the visitors the only solid contenders of getting his signature this summer.
Spurs will be looking to give Bryan Gil, signed from Sevilla, plus Atalanta duo Cristian Romero and Pierluigi Gollini their debuts as the Tottenham Hotspur Stadium welcomes a full capacity crowd.
For City, they will have injury concerns over Phil Foden and Kevin De Bruyne giving Jack Grealish the perfect chane to justify his £100m price-tag from Aston Villa.
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Team stats
Spurs have faced Man City in their opening top-flight match of the season three occasions - they are undefeated with a win and two draws.
Meanwhile, City have lost 15 away Premier League matches against their hosts today including in the last two seasons, losing 2-0 in both matches. A third 2-0 defeat is 22/1.
H2H
This will be the 165th meeting between the two sides - with City boasting the most wins (65) to Tottenham (63).
In their last four meetings in all competitions, the home side has won to nil in each of them with only two matches in the previous nine finishing with sides scoring - including the only score draw in their which finished 2-2 back in August 2019 at the Etihad Stadium.
