Tottenham midfielder Moussa Sissoko was not fit enough to start his side's Champions League semi-final first leg against Ajax.
Sissoko has missed the last three games with a groin injury and is only fit enough for the bench in the club's biggest game in recent history, though Jan Vertonghen does start.
With Harry Kane and Son Heung-min injured and suspended respectively Fernando Llorente started in attack.
Ajax were at full strength and able to pick their top stars, including Frenkie dee Jong and Matthijs de Ligt.
Tottenham XI: Lloris, Trippier, Sanchez, Alderweireld, Vertonghen, Rose, Wanyama, Rose, Eriksen, Dele, Lucas, Llorente
Subs: Gazzaniga, Foyth, Walker-Peters, Davies, Dier, Skipp, Sissoko
Ajax XI: Onana; Veltman, de Ligt, Blind, Tagliafico; Schone, De Jong, van de Beek; Ziyech, Tadic, Neres
Subs: Varela, Sinkgraven, Huntelaar, Mazraoui, Magallan, Dolberg, De Wit