Ryan Sessegnon starts at left-back for Tottenham with Jose Mourinho opting for a 4-2-3-1 formation against Southampton on New Year's Day.
Moussa Sissoko returns from suspension to start in midfield alongside Tanguy Ndombele, with Lucas Moura, Dele Alli, Christian Eriksen and Harry Kane in attack.
Giovani Lo Celso and Juan Foyth drop out for Spurs, while in-form Danny Ings leads the line for a resurgent Southampton at St Mary's.
Tottenham: Gazzaniga, Aurier, Alderweireld, Vertonghen, Sessegnon, Sissoko, Ndombele, Lucas Moura, Dele Alli, Eriksen, Kane
Subs: Sanchez, Winks, Lamela, Vorm, Lo Celso, Skipp, Tanganga
Southampton: McCarthy, Cedric, Stephens, Bednarek, Bertrand, Armstrong, Ward-Prowse, Hojbjerg, Djenepo, Ings, Redmond
Subs: Yoshida, Vestergaard, Long, Adams, Romeu, Obafemi, Gunn
Referee: Mike Dean
