Mauricio Pochettino has been dealt a double injury blow ahead of the North London Derby with Arsenal.
Tanguy Ndombele will miss the clash with the Gunners after suffering a thigh injury.
The new signing from Lyon has started on-field rehabilitation but isn't expected back until after the international break.
There was hope that it was a minor injury and he might have recovered in time for the match with the Gunners but Ndombele has not been training with the group this week and now looks set to return after the international break.
He was also at a fans' event at the Tottenham Hotspur Stadium on Tuesday where he looked to be limping around.
Kyle Walker-Peters will also miss the clash at the Emirates Stadium.
The full-back strained a hamstring in the 1-0 defeat against Newcastle United last week and is undergoing on-field rehabilitation for the injury.
Elsewhere, Juan Foyth misses out with his ankle injury, while Eric Dier is being assessed for a hip complaint.
There is good news regarding Ryan Sessegnon who is concluding the late stages of his conditioning program before returning to training with the first team squad.
