Part of the A472 was closed in both directions following a three-vehicle crash.
There was queuing traffic from Upper Race Junction at Pontypool to the Swffryd turn off for Crumlin following the crash on Friday evening.
Emergency services were at the scene along with an air ambulance.
A spokeswoman for the Welsh Ambulance service confirmed a report was logged at 5.35pm on Friday and an emergency ambulance and rapid response vehicle were sent to the scene.
Speaking shortly before 7.30pm she said: "We had reports of a road traffic collision between two cars and a lorry. We have three patients – one with back pain, one with neck pain, and another with a fracture to the leg."
When the incident took place Gwent Police posted the following notice on its Twitter page: "Emergency services are dealing with an RTC on A472 Pontypool.
"The road is closed from Pontypool roundabout including the 'old road' and also at Swffryd.
"Diversions are in place causing congestion.
"Please avoid the area if possible and find alternative routes for your journey."
