This Morning have received 156 Ofcom complaints after Eamonn Holmes compared Dr Zoe's hair to an alpaca.
On last Thursday's episode, the 61-year-old host made the comments when introducing the health expert's upcoming segment.
Dr Zoe was talking at the time about how your health can benefit from gardening and alpacas and Eamonn then said: "Your hair reminds me of an alpaca today."
Dr Zoe replied: "You just want to pet it, don't you? It's very alpaca-ish", and then added: "Don't touch my hair."
Fans of the show were quick to comment on Eamonn's remark and said they found the comment offensive on Twitter.
One Twitter user said: "Really just saw Eamonn Holmes comparing a black woman's hair to an alpaca" and another viewer added: "It wasn't humorous it was vile and unnecessary."
The presenter later apologised on the social media site, saying he was "mortified."
He said: "Hey everyone out there. If my attempt at being humorous with my friend @DrZoeWilliams was misjudged I am mortified and humbly apologise to anyone who was offended."
Dr Zoe also took to Twitter after the comments were made saying that she had "accepted" Eamonn's apology and it was "mis-judged".
She also added that Eamonn was a friend of hers.
Television watchdog Ofcom confirmed 156 complaints were made against the show, though it is not yet clear whether an investigation will be launched.