A neighbour described the shocking scene after a four-year-old girl was hit by a car.
The child suffered serious head injuries following the incident on Charlestown Road in Blackley this afternoon.
She was rushed to hospital. The air ambulance was seen landing nearby.
The road was closed in both directions at about 2.30pm, as the emergency services arrived.
It re-opened later after police had concluded their investigation at the scene.
One neighbour described the scene after the collision.
A resident of Charlestown Road said: "There was a little girl in the road, she was crying.
"There was a woman with her who looked like her grandma, who was on the phone.
"The police came quickly and there was a rapid response unit.
"It was shocking, there was a man in van who was helping too.
"The driver of the car stopped as well."
The road had been closed at its junctions with Grange Park Road and Booth Hall Road, close to Boggart Hole Clough.
GMP said a vehicle and a pedestrian had collided.
In a statement, a spokeswoman said: "At around 2.40pm on Tuesday 12 January 2020, police were called to a report of a collision on Charlestown Road, Blackley.
"Officers attended and established that a vehicle and a pedestrian had collided."
The ambulance service said the child had suffered serious head injuries.
A spokesman for North West Ambulance Service (NWAS) said: "We received a call 14:31 and have mobilised an ambulance, response car and air ambulance to the scene.
"We’ve taken a four year-old girl to hospital with serious head injuries."
Transport for Greater Manchester had asked motorists to avoid the area, with bus services being diverted.
Police are asking anyone with information to contact them, quoting 1531 of 12/01/21 or the independent charity, Crimestoppers, anonymously, on 0800 555 111.
