The Covid-19 pandemic has this race in its grip.
Tour de France organisers have confirmed that any team that has two members test positive for the coronavirus will be expelled from the Tour. This includes riders and support staff.
Belgian team Lotto has already sent home four of its members after one positive test and one "suspicious" result.
Originally scheduled for June, stage one of the three-week epic over the peaks and plains of France embarks on Saturady from Nice's Promenade des Anglais for a 154km loop. Enthusiasts will tune in to TV coverage in 190 countries.
Last Thursday, French Prime Minister Jean Castex put Nice on a Covid-19 "red zone" list with tightened health protocols.
Tiny crowds set to watch "silent" Tour
Saturday's Promenade des Anglais start in Nice will be watched by just 100 spectators.
Throughout the Tour, a virus testing unit will travel with the teams.
Current French government law limits public gatherings to 5,000.
That means a cataclysmic change for organisers, with some climbs in previous years attracting hundreds of thousands of people along the roadsides.
Health and safety protocols for riders and teams involve them being kept in virtual isolation and tested several times, with the smallest possible interaction between respective groups.
No selfies, please, we're cyclists!
Selfies will be frowned upon.
Dave Brailsford, the head of Team Ineos which has grabbed seven of the last eight Tour de France titles, admitted there remains uncertainty over the race getting to the Champs-Elysees on September 20.
"If there comes a point when it becomes too much of a risk for riders and teams, to society in general, then people need to take that on board," he said.
