Celebrities are rallying round in a campaign to help save a little girl's eyesight.
Amelia Carroll, seven, and her older brother Ollie, 10, were diagnosed in 2015 with the rare neurodegenerative condition Batten Disease.
Over time the cruel disease robs children of their abilities one by one - their speech, mobility, eyesight and ability to swallow.
Ultimately, it can also take their lives.
Ollie, sadly, cannot now walk or talk, and is blind.
For almost two years their parents Mike and Lucy Carroll, from Poynton, fought and eventually won access to ground-breaking treatment at Great Ormond Street Hospital London, funded by a pharmaceutical company.
The treatment, which replaces enzymes missing from the brain of a child with Batten Disease, consists of four hour-long brain infusions, twice monthly.
Ollie's condition deteriorated during the fight for the treatment.
Amelia became one of the youngest children in the UK to receive the enzyme replacement therapy.
But her parents said that although the treatment is making a huge impact for her, they face a new battle.
The current treatment slows down the progress of the disease, but doesn't halt the regression of sight.
Medics at Great Ormond Street however can now administer the same drug directly into the eye of a child with Batten Disease, in a bid to slow or even prevent the loss of eyesight.
The treatment isn't available on the NHS.
Manchester's celebrities - and big-hearted businesses - have stepped up to help fund the treatment brave Amelia needs.
But it's a race against time.
A group of local home improvement businesses have come together to set up a virtual raffle - backed by a long list of famous faces including Manchester City footballer Kyle Walker, comedian Jason Manford and Coronation Street stars Samia Longchambon, Tina O'Brien and Catherine Tyldesley.
The campaign aims to raise £250,000 to save Amelia's sight.
Friends say Mike and Lucy, who have five children, were devastated by watching Ollie lose his sight.
The raffle, called BIG JOBS by Big Hearts, features prizes including a £40,000 extension, a £10,000 kitchen, a £5,000 bathroom and a £5,000 patio or driveway.
All proceeds will go to the family's two fundraising appeals, Ollie's Army and, more specifically, the Save Amelia's sight campaign.
The family hope funds will also benefit other children battling the same disease.
Jo Hoddes, a friend of Mike and Lucy's from Bramhall, Stockport, launched an Instagram campaign @bigjobsbybighearts which she says is now gathering pace.
Manchester businessman and founder of international fashion brand The Couture Club, Scott Shashua, is also backing the fundraising drive after bumping into dad Mike while he was out for a run.
Scott said: "Being a father and family man myself and living so close to Mike and Lucy, I have seen first hand what the family has been though with both Ollie and Amelia.
"I wanted to get involved and show my support and hope everyone does the same."
Mike said: "As parents, all we want to do is look after and protect our children, and having to watch the two of them suffer like this is unbearable.
"We are absolutely overwhelmed with the support that we have received, and for Jo, Scott and the local celebrities stepping in to help amplify the campaign.
"Sadly we know only too well from Ollie losing his sight, that Batten Disease waits for no one, and are committed to raising every penny of the £250,000 is needed to pay for Amelia's hospital costs."
Children with CNL2 Batten Disease are born healthy.
Symptoms of the disease do not appear until around the age of three, when speech issues and seizures often occur.
Life expectancy is between six and twelve years.
It is estimated that between 30 and 50 children in the UK have Batten Disease.
