Charley Gadd has now been missing for 10 days.
The 20-year-old film student was last seen in the early hours of the morning on Saturday, December 11.
On the Friday evening, he had been to the Warehouse Project in Manchester city centre.
He was with his family - who said they had a 'lovely time' together.
Charley was near the Spar Store in St Mary's Gate at around 1.10am on Saturday when he then ran off.
His family spent hours desperately trying to find him before reporting him missing to Greater Manchester Police.
A CCTV picture of his last known movements puts him outside the Royal Exchange Theatre, heading towards St Annes Street, just before 1.15am.
In an update issued this morning (December 21), a GMP spokesperson confirmed that Charley is still missing.
They said the police investigation is still open and the investigation is ongoing.
Since his disappearance, the Manchester Evening News has reported on two searches in the River Irwell that were linked to Charley.
On Thursday and Friday last week, specialist search teams and divers were spotted in the water near the Lowry hotel.
Both searches came to an end with no updates.
Charley's parents, who do not live in the local area, said they were desperate for any news of him.
His father Jolyon Gadd, said: "We were out with Charley on Friday night and Saturday morning on the 11 December and had a lovely time together.
"We were near the Spar Store in St Mary’s Gate at around 1.10am when Charley ran off. We spent many hours then and later in the early hours looking for him before reporting him missing to the police around 11am.
"Charley is not familiar with Manchester and may have got lost and not been able to find his way back to his hotel.
"Charley is a very bright, warm, funny and loving man who everybody hugely enjoys being around.
"He is in the second year of a film and media degree course at the University of Essex in Colchester where he is well liked and flat shares with friends.
"We have heard nothing from him since he ran off and my wife and I and his brothers Bruno and Rufus are desperate for any news of him.
"We are obviously extremely worried.
"As we do not live in the area, we would ask local people and businesses to help us by looking in outbuilding, vehicles, bins, and anywhere else that Charley may have taken shelter to keep warm on Saturday morning.
"We really appreciate all the support and kind comments given by local people on social media, and ask that you please keep this in the public eye locally until we find Charley.
"However, we would ask that our privacy also please be respected at this time."
Charley is described as a white male of skinny build, who is 5ft 9 inches tall with mousy brown hair.
He was last seen wearing a red jacket and blue jeans.
Officers are keen to speak to anyone who may have seen Charley or has any information.
Anyone with information about his whereabouts should contact police on 101 or report it online at www.gmp.police.uk quoting log 149 of 12/12/2021.
