Javi Gracia will intend to use the international break as an opportunity to further implement his ideas on those who will not be representing their country this month.
Leeds have five players away on senior international duty, while a further seven will be representing their nations at youth level.
Brenden Aaronson and Weston McKennie will feature for the United States, although Tyler Adams has been forced to pull out with a hamstring injury.
Rasmus Kristensen has also been left out of Denmark's squad after his struggles since the World Cup, although he did emerge from the bench to score in Leeds' 4-2 win over Wolves on Saturday.
Elsewhere, Mateo Joseph has received a call-up for the England under-20 squad, with Darko Gyabi and Sonny Perkins starring in the under-19 squad.
Archie Gray (England U17), Crysencio Summerville (Netherlands U21s), Kristoffer Klaesson (Norway U21s), and Illan Meslier (France U21s) have also received call-ups ahead of this month's international fixtures.
Despite the Whites losing a total of 12 players due to the international break, Gracia will still have a number of first team players to work with over the next fortnight.
Those include Luke Ayling, the resurgent Junior Firpo, Jack Harrison, and Patrick Bamford. The break will provide Gracia with an ideal window to further ease Luis Sinisterra and Rodrigo back into the first team fold after long-term injury layoffs.
A full list of Leeds United's remaining players during the international break: