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Coach Bobby Petrino is 3-0 at Louisville against teams ranked in the top 10, including last Saturday's 63-20 victory over then-No. 2 Florida State.
Before Petrino's departure for the NFL's Atlanta Falcons, his Cardinals defeated third-ranked West Virginia in 2006 and 10th-ranked Boise State in 2004.
Petrino is in his second stint at Louisville. He left the school in 2007, lasted less than one full season with the Falcons, then spent four years at Arkansas before he was fired amid revelations about an extramarital affair he had with a woman with him he worked.
He spent one season as Western Kentucky's coach before returning to Louisville in 2014.
The Cardinals, who moved to No. 3 in the polls after their rout of the Seminoles, have games remaining against No. 5 Clemson and No. 6 Houston.
