In 1991, Sheffield born Helen Sharman became the first Briton in space when she blasted into orbit aboard the Soviet Soyuz TM-12 space capsule.
Sharman, a chemist for Mars, won her place to go into space by replying to a radio advert - “Astronaut wanted. No experience necessary.”
Sex Pistols and Ramones fan Michael Foale, from Lincolnshire, had tours on both the Mir platform and the International Space Station; the latter he commanded in 2003. He became a US citizen so he could join NASA.
Cambridge engineering graduate Nicholas Patrick, from North Yorkshire, also became a US citizen to pursue his space dream. He flew on two shuttle missions.
Sussex born Piers Sellers flew several missions for Nasa as a US citizen, most recently on shuttle Atlantis.
US shuttle pilot Greg Johnson was born in Britain when his father was stationed in the country in 1962.