The deaths of a 59-year-old Queensland woman and a 54-year-old man from NSW last week have been linked to the AstraZeneca vaccine.
The Therapeutic Goods Administration said both had received one dose of the vaccine and were assessed as likely having an incredibly rare blood clotting disorder that can result from it.
The TGA said 19 million vaccine doses have been given in Australia, and the benefits of vaccination far outweigh any potential risks.
Nine deaths have been linked to the AstraZeneca vaccine in Australia, with around 9.6 million AstraZeneca doses administered.
Since the start of the pandemic, there have been 1,012 deaths from 55,093 confirmed cases of COVID-19.
"Like all medicines, COVID-19 vaccines have some side effects," the TGA said in a statement.
"These need to be continuously balanced against the expected benefits in preventing illness and death from COVID-19 disease. The overwhelming majority of side effects are mild and resolve within a few days."
The Pfizer vaccine is the preferred vaccine for people under 60.
But the government's expert immunisation panel has said in areas experiencing a COVID-19 outbreak, the risk of infection poses a far greater danger to people's health than the potential side effects of the AstraZeneca vaccine.
The Chief Medical Officer has previously said that treatment of rare side effects had improved significantly, and there had only been just over a dozen serious cases.
"I would say we are getting very good at diagnosing and treating this particular event," he said.
