Stephanie Frappart will become the first woman to referee a major European men's game in the the UEFA Super Cup on August 14.
Premier League rivals Liverpool and Chelsea meet in Istanbul with Frappart poised to take charge of the contest.
The French official will be joined by the two female assistant referees who worked with her in last month's Women's World Cup final: compatriot Manuela Nicolosi and Ireland's Michelle O'Neal.
The 35-year-old became the first female to referee a Ligue 1 match in April, when she officiated a game between Amiens and Strasbourg, and she has been promoted to an elite pool of referees for French top-flight games for the new season.
In a statement, UEFA president Aleksander Ceferin said: "As an organisation, we place the utmost importance on the development of women's football in all areas.
"I hope the skill and devotion that Stephanie has shown throughout her career to reach this level will provide inspiration to millions of girls and women around Europe and show them there should be no barriers in order to reach one's dream."
UEFA chief refereeing officer Roberto Rosetti added that Frappart "fully deserves" her chance on this stage and said he hopes "this match will provide her with yet more experience as she enters the prime of her refereeing career".
The three women on the pitch at Besiktas Park will be backed by an all-male supporting cast, with Turkey's Cuneyt Cakir acting as fourth official and Frenchman Clement Turpin leading the VAR unit.
Additional reporting from Press Association
