Carlton will be without stars Jack Silvagni and Zac Williams for their AFL clash with Adelaide, while Collingwood will welcome back captain Darcy Moore against Geelong.
Silvagni underwent surgery after fracturing his hand in an exchange with Patrick Dangerfield in the first quarter of the Blues' round-seven win over the Cats.
It is hoped the defender will spend just one week on the sidelines, but he could miss two games.
Blues forward Williams has been ruled out for two weeks with a calf strain.
He suffered the injury after kicking a goal in the first quarter against Geelong.
Moore returns for the Magpies after vertigo symptoms related to an inner-ear issue ruled him out of last week's Anzac Day win over Essendon.
He is available for selection, while teammate Lachie Schultz faces a test following a hamstring injury.
Meanwhile, Adelaide are set to regain forward Riley Thilthorpe against Carlton, but they have lost defender Nick Murray for at least four weeks to knee surgery.
Thilthorpe has been cleared to play in Saturday's match after seemingly suffering a compound finger fracture in their 18-point loss to Fremantle on Friday.
His bone had pierced the skin, but the Crows confirmed on Tuesday that Thilthorpe had suffered a minor fracture.
Thilthorpe is expected to be joined in the forward line by Darcy Fogarty (shoulder), while Murray will require an arthroscopy on his troublesome knee.
Murray has continued to experience discomfort after jarring his knee at training earlier in the season, with scans proving inconclusive.
The defender could spend four to six weeks recovering after the surgery.
Luckless Sydney forward Logan McDonald could also go under the knife after suffering a stress fracture in his fibula, having already recovered from ankle surgery.
Swans defender Sam Wicks (calf) is in the frame to play in the Sydney derby, but skipper Callum Mills (foot) remains a week-to-week assessment as the club waits on scans regarding Ben Paton's calf strain.
Fremantle ruck Luke Jackson (hamstring), St Kilda's Mattaes Phillipou (leg), North Melbourne defenders Zac Fisher (hamstring) and Matt Whitlock (ankle), and Melbourne duo Jake Melksham (leg) and Daniel Turner (concussion) are all available for selection.
Hawthorn have lost defenders Karl Amon and Jack Scrimshaw to concussion, while Essendon pair Matt Gueli (hamstring) and Nik Cox (calf) will make their return to football via the VFL.
