The University and College Union (UCU) have slammed SK College Group - which runs St Helens College and Knowsley Community College - for its plans to axe 22 members of staff.
UCU said the college group plans to axe nearly two dozen from a pool of 76 teachers it has put at risk of redundancy and the plans are "the fourth round" of redundancies in 12 months.
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UCU said the plans would mean almost one in ten (8.8%) teachers across the college would go - including in accounting, science, engineering and sport - and would also see" over half the teachers in computing" sacked.
But the SK College Group said while it is "regrettable" that the college has had to serve notice of a number of redundancies, new academic posts have been created that they anticipate will be filled by staff currently at risk.
They said they are now in consultation with the staff affected and the trade unions and "will do everything they can" to mitigate against job losses
The union said a fourth set of job cuts in less than 12 months threatened to cause serious damage to students and to educational opportunities across the region.
It said if managers want to live up to the college’s professed vision then they need to immediately halt these cuts and concentrate on supporting staff, and creating a caring learning and working environment.
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UCU regional official Martyn Moss said: "Putting a further 76 teachers at risk of redundancy after already sacking staff in three sets of redundancies this year points to a failure of management.
"The college says it wants to create a caring learning and working environment, but getting rid of expert teachers doesn’t sound like a good way to improve learning.
"The college says it wants to support students into good jobs at the same time as halving provision in essential skills like computing. Management appear to have no strategy other than sacking more and more staff.
"The college needs to immediately reverse these plans and work with UCU to build a proper strategy to protect jobs and create a caring learning environment. If it refuses to so, staff are determined to fight these cuts."
In a statement, the SK College Group said: "It is regrettable that the College has had to serve notice of a number of redundancies; however, new academic posts have been created that we anticipate will be filled by staff currently at risk.
"The College is committed to ensuring our students are supported and nurtured to exceed their ambitions and goals and the new roles will focus purely on supporting our students to succeed, and enhancing their wider curriculum experiences whilst in our care.
"We are now in consultation with the staff affected and the trade unions and will do everything we can to mitigate against job losses."
UCU’s members are meeting on Tuesday, June 29, to decide "how to fight this latest round of job cuts."