Jose Mourinho will want to get back to winning ways with a more usual looking Tottenham Hotspur team under him.
He changed things around against Bayern Munich in midweek to give many a rest and some a few minutes.
Ryan Sessegnon and Juan Foyth pushed their claims for starting spots with their performances in Germany, but Mourinho has already admitted the latter is not going to start again and could well find himself replaced by the fresher Sanchez.
Foyth made his Premier League debut at Wolves last season, impressing until he conceded two second half penalties.
Sessegnon has given himself a chance but may not be fit enough to manage two starts within a couple of days after almost six months between his last two.
Mourinho has also said Giovano Lo Celso will not start while Tanguy Ndombele, Ben Davies, Erik Lamela, Hugo Lloris and Michel Vorm are all out injured.
Harry Winks is back in training while Harry Kane, Dele Alli, Jan Vertonghen and Serge Aurier all return after left at home to train in midweek.
Here is the team we reckon Mourinho will go with, making six changes to the team in Munich.
(4-2-3-1): Gazzaniga; Aurier, Sanchez, Alderweireld, Vertonghen; Dier, Sissoko; Lucas, Alli, Son; Kane.
