Jurgen Klopp may have to juggle his Liverpool squad against Southampton following a draining Uefa Super Cup victory over Chelsea in midweek.
Liverpool beat Chelsea on penalties to collect their second trophy of 2019, but a few of Klopp's men looked out on their feet during extra-time as humid conditions took their toll.
Adrian will continue to deputise in goal for the injured Alisson Becker, who is out for a few weeks with a calf injury.
The back-up keeper will be full of confidence though, having made the decisive save in the Super Cup shootout.
Sadio Mane could well start once again after two goals against Chelsea, and was likely taken off versus the Blues with Saturday's game in mind.
Trent Alexander-Arnold will almost certainly return to Klopp's starting XI along with Roberto Firmino, and Georginio Wijnaldum could come in for Fabinho after the Brazilian played 120 minutes vs Chelsea.
Nathaniel Clyne is out with an ACL injury, while Naby Keita missed the Super Cup due to a muscle strain and is unlikely to feature at St Mary's.
The Saints have no injury concerns, but Ralph Hasenhuttl has plenty to ponder after a damaging 3-0 defeat at Burnley.
Pierre-Emile Hojbjerg may play in midfield to improve ball retention, with Hasenhuttl aiming to keep things tight and play deep to avoid being caught on the counter.
Predicted lineups
Southampton XI: Gunn, Bednarek, Stephens, Vestergaard, Valery, Romeu, Hojbjerg, Ward-Prowse, Bertrand, Redmond, Ings
Liverpool XI: Adrian, Alexander-Arnold, Van Dijk, Matip, Robertson, Wijnaldum, Fabinho, Henderson, Salah, Firmino, Mane
