Jurgen Klopp is expected to juggle his Liverpool squad against Southampton this afternoon following a draining Uefa Super Cup win over Chelsea in midweek.
Liverpool beat Chelsea on penalties to collect their second trophy of 2019, but a few of Klopp's men looked out on their feet during extra-time as humid conditions took their toll.
Goalkeeper Adrian is a doubt after an accidental collision with a supporter in the immediate aftermath of the shootout left the Spaniard with a swollen ankle.
Klopp is already without first-choice shot-stopper Alisson Becker because of a calf injury so if Adrian is unavailable at St Mary's, then Andy Lonergan is likely to be deployed.
Sadio Mane could well start once again after two goals against Chelsea, and was likely taken off versus the Blues with Saturday's game in mind.
Trent Alexander-Arnold will almost certainly return to Klopp's starting XI along with Roberto Firmino, and Georginio Wijnaldum could come in for Fabinho after the Brazilian played 120 minutes vs Chelsea.
Nathaniel Clyne is out with an ACL injury, while Naby Keita missed the Super Cup due to a muscle strain and is is out again at St Mary's.
The Saints have no injury concerns, but Ralph Hasenhuttl has plenty to ponder after a damaging 3-0 defeat at Burnley.
Pierre-Emile Hojbjerg has recovered from illness and may play in midfield to improve ball retention, with Hasenhuttl aiming to keep things tight and play deep to avoid being caught on the counter.
As for Southampton, the hosts should have new signing Kevin Danso available. The Austria defender has joined up with the squad this week after his deadline-day switch from German club Augsburg.
Winger Moussa Djenepo could be set for a debut having been an unused substitute in the 3-0 defeat at Burnley after his summer move from Belgian side Standard Liege and international duty with Mali.
Predicted lineups
Southampton XI: Gunn, Bednarek, Stephens, Vestergaard, Valery, Romeu, Hojbjerg, Ward-Prowse, Bertrand, Redmond, Ings
Liverpool XI: Lonergan, Alexander-Arnold, Van Dijk, Matip, Robertson, Wijnaldum, Fabinho, Henderson, Salah, Firmino, Mane
Southampton provisional squad: Gunn, Vestergaard, Stephens, Bertrand, Bednarek, Valery, Romeu, Ward-Prowse, Redmond, Ings, Adams, McCarthy, Soares, Yoshida, Djenepo, Boufal, Hojbjerg, Obafemi, Danso.
Liverpool provisional squad: Adrian, Lonergan, Kelleher, Hoever, Alexander-Arnold, Van Dijk, Gomez, Robertson, Matip, Henderson, Fabinho, Wijnaldum, Milner, Elliott, Oxlade-Chamberlain, Lallana, Shaqiri, Brewster, Firmino, Mane, Salah, Origi.
