Leeds United head to St. Mary's looking to build on their first win of the season against Watford.
Marcelo Bielsa's side have endured a difficult start to the 2021/22 campaign but picked up their first three points of the season in their last outing against the Hornets.
The Whites face a Southampton side who are yet to win a league game this season, but are just two points behind Leeds.
The Saints were beaten by Chelsea and Wolves in their two previous outings and Ralph Hassenhuttl's side are in desperate need of a win.
The Whites head to the south coast without Patrick Bamford but Kalvin Phillips could return for Bielsa's side.
When is Southampton vs Leeds United?
The game is on Sunday, October 16 at St. Mary's and kicks off at 3pm.
Is Southampton vs Leeds on TV?
The game will not be broadcast live on TV in the UK, due to the 3pm blackout rule.
Where can I watch highlights?
There will be highlights packages on Sky Sports Youtube shortly after the game, as well as on BBC One's Match of the Day.
The flagship highlights show will be broadcast at 10.30pm on BBC One on Saturday night.
How else can I follow?
LeedsLive will be in position, reporting from the stadium. There will be a live blog running, as well as post-match reaction, player ratings and press conference comments.
