Southampton will face the Danish champions Midtjylland in the play-off round for a place in the Europa League group stage.
Ronald Koeman’s team, who beat Vitesse Arnhem 3-0 on aggregate in the third qualifying round, will play at home in the first leg on 20 August and travel to Denmark a week later.
Midtjylland’s majority shareholder is the Brentford chairman Matthew Benham, who has been a driving force behind an analytics-based approach that sees the club make heavy use of statistics and mathematical modelling in its recruitment and team set-up.
The Danish side entered this season’s Champions League but were beaten on away goals in the third qualifying round by the Cypriot side Apoel. Among their squad is a former Southampton academy player, the Finnish midfielder Tim Sparv.
The draw in full
Altach (Austria) v Belenenses (Portugal)
Panathinaikos (Greece) v Qabala (Azerbaijan)
Milsami Orhei (Moldova) v Saint-Étienne (France)
Lech Poznan (Poland) v Videoton (Hungary)
Zilina (Slovakia) v Athletic Bilbao (Spain)
Southampton (England) v Midtjylland (Denmark)
Jablonec (Czech Republic) v Ajax (Netherlands)
Dinamo Minsk (Belarus) v Salzburg (Austria)
Steaua Bucharest (Romania) v Rosenborg (Norway)
Astra Giurgiu (Romania) v AZ Alkmaar (Netherlands)
Young Boys (Switzerland) v Qarabag (Azerbaijan)
Rabotnicki (Macedonia) v Rubin Kazan (Russia)
Zorya Luhansk (Ukraine) v Legia Warsaw (Poland)
Odds (Norway) v Borussia Dortmund (Germany)
Molde (Norway) v Standard Liege (Belgium)
Slovan Liberec (Czech Republic) v Hajduk Split (Croatia)
Viktoria Plzen (Czech Republic) v Vojvodina (Serbia)
Krasnodar (Russia) v HJK Helsinki (Finland)
PAOK (Greece) v Brondby (Denmark)
Atromitos (Greece) v Fenerbahce (Turkey)
Bordeaux (France) v Kairat Almaty (Kazakhstan)
