Liverpool despatched MK Dons in the Carabao Cup in midweek and Jurgen Klopp will revert back to his accustomed starting XI as his side resume their Premier League title charge.
The Reds are expected to extend their 100 per cent league start by notching their seventh straight win, but it will be no cakewalk at a sold-out Bramall Lane.
The Blades fought back from 2-0 down to take a point off Chelsea at Stamford Bridge and won at Goodison Park last week.
Can Klopp's side close to within two victories of Chelsea's best-ever Premier League start when they won nine on the bounce in 2005?
Here's how you can follow the action...
TV channel and live stream information
The match will be televised live on BT Sport 1, with coverage starting from 12pm. BT Sport subscribers will be able to stream the match online via the video player and the BT Sport app.
You can follow all of the action with Standard Sport's LIVE blog.
You can follow all the action and analysis on Standard Sport's LIVE blog with David Lynch at Bramall Lane.
