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The Independent UK
The Independent UK
National
Vishwam Sankaran

Secrets of hibernating animals could unlock new Alzheimer’s treatments

  • Recent studies indicate that the remarkable abilities of hibernating animals, such as avoiding muscle and nerve decay and maintaining health despite significant weight changes, are also present in human DNA.
  • These animals demonstrate recovery from symptoms akin to those observed in human conditions like diabetes, Alzheimer's, and stroke upon emerging from hibernation.
  • The research highlights the “fat mass and obesity locus” (FTO) gene cluster, which regulates adjacent genes to control metabolism and weight in hibernators.
  • Experiments involving mutations to hibernator-specific gene regions in mice demonstrated alterations in their metabolism, weight gain, and recovery from a hibernation-like state.
  • Scientists suggest that identifying and understanding these genetic control switches could pave the way for new treatments for diabetes, Alzheimer's, and other age-related diseases in humans.

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