Hundreds of thousands of businesses will be forced to close from Thursday under new measures to prevent a "medical and moral disaster" for the NHS amid a surge in coronavirus cases in England.
Pubs, restaurants, gyms and non-essential shops will close for at least four weeks, Boris Johnson announced on Saturday.
However, education will continue as normal, including students attending university across England.
The prime minister told a Downing Street that he was "truly, truly sorry" for the impact on businesses as he announced a 30-day furlough extension starting this week.
He warned the country is heading for a "peak of mortality" worse than in April.
Mandatory closures will start at 00:01 on Thursday and run for at least four weeks until December 2 - after this date, the country should go back to 'tiered' restrictions.
Johnson said under new measures, only a small list of retailers will be allowed to trade, including supermarkets and pharmacies.
Banks and post offices will stay open as they provide a vital service to the community.
However, non-essential stores, such as GAME, Primark and Ikea will be ordered to close their doors.
The mandated closures will also include bars and restaurants which will only be allowed to trade for takeaways and deliveries.
Shops and businesses that will stay open during lockdown

These are the businesses that will continue to stay open this month:
Petrol stations
Vets
Newsagents
Pet shops
Supermarkets
Pharmacies
Takeaways and food deliveries
Health shops
Medical services ie dentists
Hardware stores
Garden centres
Retail shops in hospitals
Bicycle shops
Laundrettes and dry cleaners
Undertakers
Banks, building societies
Short-term loan providers, credit unions and ATM machines
Storage and distribution centres
Post Offices
Car rental services and car parks near vital services such as supermarkets
Public toilets
Food banks and shelters
Car garages and repair shops
What businesses will be forced to close from Thursday?

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Gyms
Restaurants and cafés
Pubs
Bars
Non-essential shops, including electronics and clothing stores
Hairdressers and barbers
Nail salons
Spas and beauty bars
Clothing and electronics stores
Vehicle showrooms
Travel agents
Betting shops
Auction houses
Tailors
Car washes
Tobacco and vape shops
Bowling alleys, leisure centres and gyms, sports facilities including swimming pools, golf courses and driving ranges, dance studios, stables and riding centres, soft play facilities, climbing walls and climbing centres, archery and shooting ranges, water and theme parks.
Theatres, concert halls, cinemas, museums and galleries, casinos, adult gaming centres and arcades, bingo halls, bowling alleys, concert halls, zoos and other animal attractions, botanical gardens.
Body and skin piercing studios, non-medical acupuncture, and tanning salons.
Places of Worship
Libraries
Community Centres
Museums and galleries
Amusement arcades
What are the latest lockdown rules and can I still go out?

Under new measures, schools and universities will remain open, however pubs and restaurants will have to close unless they are serving takeaways.
These are the latest lockdown rules:
Pubs and restaurants will close (unless they are serving takeaways/deliveries
Nurseries and schools will remain open
Non-essential international travel will be banned - except for work
Overnight stays and UK staycations banned
All non-essential retail will close, but supermarkets will stay open
There will be a nationwide ban on people mixing indoors - except for childcare and those in social bubbles
No limit on exercise, however gyms will be ordered to close
Parliament and courts will stay open
Building projects will continue where possible
People will be asked to work from home where possible
Meeting in private gardens will be banned
Anyone caught breaking the rules will be liable for a £30 fine, rising to up to £1,000 for repeat offences
Click-and-collect shopping will remain open
Clinically vulnerable people are asked to be "especially careful" but people are not being asked to resume shielding.