Sir Sadiq Khan and the Prime Minister are set to discuss forcing through plans for thousands of new homes in London amid council opposition.
Enfield council last week announced it had “formally withdrawn” support for 21,000 new homes due to be built on large swathes of Green Belt land in Crews Hill and Chase Park.
Labour had supported the project, but the party lost control of the borough at the local elections on May 7.
A new Tory-led minority administration, propped up by the Green Party, said the town hall would no longer be backing the “new town” and would also reject Tottenham Hotspur's plan for a women’s training facility on Whitewebbs Park.
Mayors from across England, including Sir Sadiq, will meet with Sir Keir Starmer on Thursday to discuss devolution, infrastructure and local transport.
Sir Keir Starmer is expected to tell mayors that the Government will back them to push them through large projects that have stalled or been watered down.
This includes challenging Enfield council’s refusal to support the proposed new town, with the Prime Minister expected to say that decisions will be taken in the national interest.
He will also confirm action to deliver new public transport services, including that Government is in discussion with the Mayor of London to bring the local services from Moorgate to Welwyn Garden City and Stevenage under Transport for London control.
Sir Keir said: “For too long, Britain has been held back by a system that says no, delaying projects, blocking growth and leaving communities behind.
“We’re turning that on its head by backing our mayors to get Britain building again, with spades in the ground and more jobs across the country. There will always be the naysayers and the blockers, but we cannot afford to give into them - because it will be the next generation that suffers.
"This government is backing mayors with the biggest devolution drive in a generation, putting real power in the hands of local leaders, because those with skin in the game know best what their communities need. That is the right thing to do for communities, and it's the right thing to do for growth."
A spokesperson for the Mayor of London added: “Crews Hill, and other sites in the borough, represent a significant opportunity to deliver sustainable, high-quality neighbourhoods, improve the quality of and access to nature and local green spaces, and tackle London’s acute housing crisis.
“Alongside the Government we will continue to work closely with councillors in Enfield to further develop plans at Crews Hill, including proposals for extensive consultation with the local community.”