Tottenham face a tricky trip to Leicester in the midday kick-off on Saturday just days after their midweek exploits.
Mauricio Pochettino's side were involved in their Champions League opener with Olympiakos on Wednesday, and have been given limited time to prepare for the clash at the King Power stadium.
Former Fox Robbie Savage feels Spurs could suffer a European hangover against Brendan Rodgers' men, who have started the season in good form.
No doubt all eyes will be on the clash of the weekend at Stamford Bridge as league leaders Liverpool face old rivals Chelsea .
There was little to choose between the two sides in last month's Super Cup final, and Sav predicts it could be equally as tight this time round.
Man City will be hoping the Blues can take some points off their title challengers as they aim to bounce back from last weeks defeat to Norwich.
The defending champions host a Watford side looking re-energised following Quique Sanchez Flores' return to the hot seat, and will be keen to avenge their 6-0 FA Cup final hammering in May.
Arsenal's performance against the Hornets last Sunday has come under criticism, and the Gunners have an important clash at home to Aston Villa.
Across London, West Ham host Man United in the first of the games on Super Sunday, while Crystal Palace welcome the visit of Wolves .
There's a local derby down on the south coast as Bournemouth make the trip to St. Mary's to take on Southampton , as Brighton make the long trip up to Newcastle .
Fresh from their victory over City, Norwich head to Turf Moor for a difficult test at Burnley , and fellow Premier League new boys Sheffield United will look to take something from the inconsistent Everton .
Here's how Sav sees the weekend's action panning out...
Robbie Savage's Premier League predictions
Southampton 1-1 Bournemouth
Leicester 2-1 Tottenham
Burnley 2-1 Norwich
Everton 2-0 Sheffield United
Man City 3-0 Watford
Newcastle 1-0 Brighton
Palace 2-1 Wolves
West Ham 1-2 Man Utd
Arsenal 2-0 Aston Villa
Chelsea 2-3 Liverpool
