Collingwood have been forced into isolation just a day out from their Anzac Day clash with Essendon due to Perth's COVID-19 lockdown.
After playing West Coast at Optus Stadium in round-five on April 16, the Magpies have been told to be tested for coronavirus before facing the Bombers in their blockbuster match at the MCG on Sunday.
A light training session at the club on Saturday has been cancelled, with Collingwood to conduct their pre-game meetings via video link instead.
The Magpies are expected to be notified of their test results on Saturday afternoon or early Sunday morning.
If results are negative, the traditional Anzac Day game will go ahead as planned in front of a crowd of up to 85,000 at the home of football.
West Coast are preparing to play Geelong at GMHBA Stadium on Saturday but all Eagles players have returned negative test results.
Travelling Eagles supporters are likely to be turned away from the game in a similar situation to the round-two game between the Cats and the Brisbane Lions.
Perth and the Peel region entered a snap 72-hour lockdown from Friday midnight WST after a man contracted COVID-19 while staying at one of WA's quarantine hotels.
The lockdown is due to end at midnight WST on Monday.
Saturday night's AFL clash between Fremantle and North Melbourne at Optus Stadium will go ahead but without crowds.
Up north, Brisbane Roar chief executive David Pourre is demanding a mindset shift from authorities during COVID outbreaks after his team's high-profile Anzac Day A-League clash with Perth Glory was postponed.
The Roar announced on Saturday the clash with the Glory at Moreton Daily Stadium wouldn't go ahead following the imposition of the three-day lockdown in Perth.
While the Glory were granted an exemption to travel to Queensland to play Sunday's match by WA authorities, AAP understands players and staff would have had to enter a 14-day hotel quarantine upon arrival in Brisbane.
Pourre says the decision to postpone the fixture is devastating not just in terms of a financial cost to his club but also to game-day staff and vendors.
"This is not going away. COVID plans across our club, COVID plans across our league are in place for a reason," Pourre told AAP.
"Our first priority is always protection of our players and staff and we believe the border shutdown that's been put in place may be good from one element or perspective but it's just not about protecting lives it's also about protecting livelihoods.
"This is our job.
"This game could have gone ahead, WA border force has granted an exemption for Perth to travel and return however, Queensland has taken the approach - a very hard approach - around a 14-day hard quarantine to anyone coming from Perth.
"We've got to look at real and practical ways of actually making things happen."
Details of the rescheduled match will be announced at a later date, while Glory now have seven straight home fixtures which could create a headache for the entire competition if the lockdown extends past its scheduled finish at midnight WST on Monday.
Brisbane's NBL fixture on Anzac Day at Nissan Arena against the South East Melbourne Phoenix was also postponed.
Super Rugby's Queensland Reds and Western Force are also uncertain about their travel plans after Friday's game at HBF Park.
The Force set up a qualifying final against the Brumbies in Canberra next Saturday with their 30-27 triumph over the previously unbeaten Reds, who are due to host the grand final in Brisbane on May 8.