Huge plumes of smoke were sent billowing across the city after a blaze broke out at a hospice shop in Aintree.
Six fire engines are at the scene of the fire in Warbreck Moor, where crews were called just after 12.30pm.
Road closures are currently in place from Signey Street to Caldy Road and people are being asked to avoid the area.
Photos taken at the scene show the blaze ripping through the warehouse of a St Joseph's Hospice furniture shop.
Residents are being told to keep their windows and doors shut to the amount of smoke in the area.
Mike Parr, chief executive of St Joseph's Hospice, said everyone has been evacuated safely from the building.
In a statement Mr Parr said: "At around 12.30pm this afternoon (Tuesday, May 25) a fire broke out in the warehouse of our furniture shop on Warbeck Moor.
"Thankfully everyone was evacuated safely and the fire service is currently at the scene. We will provide further updates as soon as we are able to."
Footage taken at the scene shows the scale of the emergency service response to the fire as smoke continues to billow into the air.
Merseyside Fire and Rescue Service said firefighters, wearing breathing apparatus, are tackling the fire using hose reel jets.
In a statement they said: "MFRS are in attendance at an incident in Warbreck Moor, Aintree.
"Crews were alerted at 12.34pm and on scene at 12.36pm. Six engines are at the scene.
On arrival, crews found a building well alight.
"Firefighters, wearing breathing apparatus, are tackling the fire using hose reel jets.
"The public - and motorists - are asked to avoid the area and residents should keep doors and windows closed due to smoke in the area."
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