Penrith have opened up a significant buffer at the top of the NRL ladder, seeing off the Warriors despite missing the majority of their State of Origin stars in a nailbiting 20-18 win.
The Panthers are now four points clear of the second-placed Warriors after NSW debutant Casey McLean bagged two tries at CommBank Stadium.
McLean, who made his Blues debut off the bench on Wednesday night following Tolu Koula's injury, was the only Penrith or Warriors player who featured in the Origin opener to return to club action.
Panthers coach Ivan Cleary opted to sit Nathan Cleary, Isaah Yeo and Brian To'o out of Sunday's top-of-the-table clash, while Warriors counterpart Andrew Webster rested Kurt Capewell and Mitch Barnett.
But Penrith (11-1), led by some heroic plays from Dylan Edwards, didn't need their big guns to further underline their credentials as NRL premiership favourites in one of the games of the season.