Queensland forward Pat Carrigan and centre Gehamat Shibasaki are both out of the second State of Origin clash in injury blows that have also rocked Brisbane.
Carrigan left the Brisbane dressing rooms in a moonboot after their 30-26 loss to St George Illawarra and scans have revealed a syndesmosis injury that is expected to rule him out of action for three to four weeks.
Shibasaki, who was on the six-man bench and did not take the field in the Maroons' narrow 22-20 loss to NSW in Sydney on Wednesday night, was diagnosed with a grade two MCL injury after the Dragons clash and will miss five to six weeks.
That time frame will rule him out of the entire Origin series.