Arsenal manager Mikel Arteta is expected to make a host of changes as his side face Dundalk on Thursday night.
Arteta is without a number of central defenders for Thursday's match at Emirates Stadium, with Shkodran Mustafi and Gabriel Magalhaes the only two fit centre backs.
William Saliba and Sokratis Papastathopoulos have not been registered to play in the European competition.
Meanwhile, Reiss Nelson could be set for a chance in attack after Arteta revealed that the 20-year-old decided to stay and fight for his place after being told he could go out on loan this season.
Eddie Nketiah and Ainsley Maitland-Niles are also expected to be handed starts, with Mohamed Elneny set for a return to midfield alongside Joe Willock.
The Europa League clash will see the two teams come up against eachother for the first time, with Arteta praising the Irish side's character after they reached the group stage of the competition for the second time in five years.
"We've got some Irish staff here and there are a lot of positive things about them," said Arteta.
"From what I've seen they've got a really determined coach that has found a really good cohesion with the team.
"You can see in every reaction when they are playing, how united they are. They're really well organised, they make it really hard and they will be coming here with incredible passion.
"They're underdogs and that will give them a lot of energy and I expect them to be at full gas tomorrow, trying to beat us here.
Arsenal predicted XI: Leno, Cedric, Mustafi, Gabriel, Kolasinac, Elneny, Willock, Maitland-Niles, Pepe, Nelson, Nketiah.
