Red Bull Salzburg and Genk know they must beat each other in the Champions League to stand any chance of getting out of Group E.
Liverpool and Napoli are firm favourites to qualify for the knockout stages and the Austrian and Belgian relative minnows will look to take points off the big guns before meeting against in late November.
Red Bull are in the Champions League group stage for only the second time and first since 1994-95, with Genk racking up their third outing and first for eight years.
The Belgian champions will have to win at Europe's top table for the first time to stand any chance of even reaching the Europa League but a trip to Austria will be daunting for all opponents involved in the group.
Here's how you can see the Champions League group stage game on TV and online...
TV channel, live stream and online coverage
The match will be televised live on BT Sport Extra 4 with coverage starting just before kick-off at 7.45pm.
BT Sport subscribers will be able to stream the match online via the video player and the BT Sport app.
You can also follow all the action with Standard Sport's LIVE blog from Stamford Bridge