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USA Today Sports Media Group

Rams open as slim favorites vs. Bills in 2022 season opener

The 2022 NFL season kicks off with a bang in Week 1 with the defending champions hosting the Super Bowl favorites. The Los Angeles Rams will take on the Buffalo Bills in the opener on Thursday Night Football in Week 1, a marquee matchup between two of the best teams in football.

The Rams get the benefit of being at home as they begin their title defense, but the Bills might be the most talented team on their schedule. Yet, despite the Bills’ sky-high expectations, the Rams are still favored in that game — albeit, barely.

According to Tipico Sportsbook, the Rams are 0.5-point favorites over the Bills. The over/under is set at 52.5 points, the second-highest total of Week 1.

If you want to bet on the Rams to win outright, the money line is -112, so a $112 wager on the Rams will net $100. Being at home and with the excitement of opening the 2022 season, Los Angeles is a pretty good bet in that game.