The Queen says she hopes the coronavirus crisis will prove "this generation is as strong as any" in a rare special address to the Commonwealth.
She urged Britons and all Commonwealth members to value self-discipline and resolve during the crisis.
The monarch also used the address — only the fifth of its type — to personally thank frontline health workers and others carrying out essential works during the crisis.
"I am speaking to you at what I know is an increasingly challenging time," she said from partial isolation in Windsor Castle.
"A time of disruption in the life of our country; a disruption that has brought grief to some, financial difficulties to many, and enormous changes to the daily lives of us all."
The Queen gave special thanks to those workers tackling the crisis at its forefront.
"I want to thank everyone on the NHS [National Health Service] front line, as well as care workers and those carrying out essential roles, who selflessly continue their day-to-day duties outside the home in support of us all," she said.
"I am sure the nation will join me in assuring you that what you do is appreciated and every hour of your hard work brings us closer to a return to more normal times.
"I also want to thank those of you who are staying at home, thereby helping to protect the vulnerable and sparing many families the pain already felt by those who have lost loved ones.
"Together we are tackling this disease, and I want to reassure you that if we remain united and resolute, then we will overcome it."
She said she hoped people would deal with the crisis with "self-discipline" and "quiet, good-humoured resolve".
"Across the Commonwealth and around the world, we have seen heart-warming stories of people coming together to help others, be it through delivering food parcels and medicines, checking on neighbours, or converting businesses to help the relief effort," she said.
"And though self-isolating may at times be hard, many people of all faiths, and of none, are discovering that it presents an opportunity to slow down, pause and reflect, in prayer or meditation.
"It reminds me of the very first broadcast I made, in 1940, helped by my sister. We, as children, spoke from here at Windsor to children who had been evacuated from their homes and sent away for their own safety.
"Today, once again, many will feel a painful sense of separation from their loved ones. But now, as then, we know, deep down, that it is the right thing to do.
"While we have faced challenges before, this one is different.
"This time we join with all nations across the globe in a common endeavour, using the great advances of science and our instinctive compassion to heal. We will succeed — and that success will belong to every one of us.
"We should take comfort that while we may have more still to endure, better days will return: we will be with our friends again; we will be with our families again; we will meet again."
