Fresh from securing their first win at Stamford Bridge this season, Chelsea will be hoping to pick up their first three points in this year's Champions League.
The Blues kicked off their European campaign with a 1-0 defeat at home to Valencia two weeks ago, with Ross Barkley firing over a late penalty in a bid to rescue his side a point.
But Frank Lampard's side returned to winning ways in the Premier League at the weekend after two second half goals from Jorginho and Willian handed his side a 2-0 win.
While their opponents on Wednesday night, Lille, come into the game on the back of a 1-1 draw with Nice on Saturday night, and suffered a 3-0 defeat to Ajax in their opening group game.
And pundits are predicting a tight encounter in France.
Charlie Nicholas - Sky Sports - prediction 1-1
This is a very awkward tie. I am trying to work out how Frank Lampard goes about this.
When is the right time to put all of these youngsters in together? If he can use them, he would much prefer to use them at home.
After being on a high, you do not want to flip the switch and raise question marks. He will go with a solid base I think for that reason.
Lille drew 1-1 away at Nice at the weekend and are sitting pretty comfortable in fourth, so this is a test for Chelsea.
I think they may get something from this, but it will be a more experienced Chelsea side that we see.
Michael Owen - BetVictor - prediction score draw
Lille have not won in their last nine home games in European competition and both they and Chelsea lost their opening group game without scoring.
Both sides will be looking to kick-start their Champions League campaign, but I feel they will have to settle for a point apiece in northern France.
